For instance, it is known that the stable re-expression of SFRP1 in ccRCC cells results in decreased expression of Wnt target genes, decreased growth in cell culture, inhibition of anchorage-independent growth, and decreased tumor growth, supporting the hypothesis that loss of SFRP1 is an early, aberrant molecular event in renal cell carcinogenesis [39]. The gene discussed is SFRP1; the disease is nonpapillary renal cell carcinoma.