Indeed, as shown in Figure 4A, in ccRCC samples there was a significant increase (p-value = 4.48E-06) of the ratio of the isoforms (i.e., p96 splice variant) including the cassette exon analyzed, and only 15% of mature DAB2 transcripts resulted from the skipping of this exon. The gene discussed is DAB2; the disease is nonpapillary renal cell carcinoma.