This study identifies four novel potential biomarkers for ccRCC (PTP4A3, CAV2, LAMA4 and KCNJ1) and other two genes recently established also by other authors to be implicated in ccRCC (SFRP1 and TCF21) support the reliability of our investigation. The gene discussed is SFRP1; the disease is nonpapillary renal cell carcinoma.