Using WM239 cells, the requirement for MMP-2 activity during tumor cell extravasation was evaluated using recombinant CBD (collagen binding domain protein) [7] and MMP-2 HxCD (hemopexin C domain protein) [45], which are known to exert stimulatory and inhibitory effects on pro-MMP-2 activation, respectively (Figure 2D). The gene discussed is MMP2; the disease is neoplasm.