Leroy-Dudal et al. showed that MMP-2 and αv integrins are important for the invasion endothelial monolayers by ovarian carcinoma cells in vitro [20], while Kargozaran et al. suggested that MMP-2 is produced by the endothelium during cancer cell transmigration of an endothelial-basement membrane barrier [21]. This evidence concerns the gene MMP2 and cancer.