In the tertile analysis, PTGS2 G-765C homozygous wildtype carriers were at low risk of CRC by high intake of fibre (IRR=0.71, 95% CI: 0.55-0.90, Pint=0.004), and fruit (IRR=0.73, 95% CI: 0.57-0.93, Pint=0.006).No interaction between any genotypes and cereal in relation to risk of CRC was found (Table 4). This evidence concerns the gene PTGS2 and colorectal carcinoma.