PTGS2 and colorectal carcinoma: We now extend our previous studies of IL10, IL1B and PTGS2 polymorphisms in relation to diet and colorectal carcinogenesis in a study group of three hundred and seventy-eight CRC cases and 775 participants in a randomly selected comparison group [3,17,18] studies to a larger cohort with more than twice the number of cases and members of the comparison group and include more dietary factors.