CDK4 and breast carcinoma: Eight known cancer genes from these compiled gene lists were found among the FBC candidate drivers: GATA3, CCNE1, PRCC, MALM2, CDK4, GRB7, NFIB and VTI1A. Among these, GATA3, CCNE1, CDK4 and GRB7 are known drivers of breast cancer [26,27].