FOXO3 and neoplasm: The Chi square analysis showed that the expression level of FOXO3a in tumor tissues was significantly correlated with various clinicopathological parameters, such as tumor size (p = 0.007), histological grade (p = 0.029), depth of invasion (p = 0.049), local lymph node metastasis (p = 0.013), distance metastasis (p = 0.013) and AJCC staging (p<0.001), but not with age (p = 0.478) or gender (p = 0.165) (Table 1).