BMPR2 and pulmonary arterial hypertension: [19]. Reynolds et al. showed that experimental function loss of the BMPR2 gene leads to PAH [22]. Li et al. has shown that loss of BMPR2 function contributes to abnormal pulmonary artery smooth muscle cell proliferation and predisposes to apoptosis of pulmonary endothelial cells [23]. We confirmed the results of Girerd et al., who showed that BMPR2 positive PAH patients have worse hemodynamics at diagnosis [15].