MMP2 and hepatocellular carcinoma: miRNAs have been reported to be involved in regulation of angiogenesis through different mechanisms, including miR-214 reducing the secretion of the hepatoma-derived growth factor in human hepatoma [43], miR-221 regulating andiogenin and CXCL16 expression levels [44], and miR-29b reducing the expression of matrix metalloproteinase 2 [45].