EPAS1 and neoplasm: The downregulation of miR-17 and miR-20a, and upregulation of HIF-2α in TAMs cultured in vitro were independent of hypoxia, and HIF-2α in these macrophages was still capable of promoting transcription of a set of proangiogenic genes, indicating its regulatory role in the proangiogenic functions of TAMs within a tumor (Figure 5).