For instance, CLCN5 is reported to be associated with several phenotypes, such as proteinuria, hypercalciuric nephrocalcinosis (OMIM: 308990) [38], [39], dent disease (OMIM: 300009) [40] and nephrolithiasis, type I (OMIM: 310468) [41] in humans; while its orthologous gene Clcn5 is known to be responsible for increased urine protein level (MP: 0002962), abnormal renal protein reabsorption (MP: 0011445), abnormal tooth development (MP: 0000116) and nephrocalcinosis (MP: 0003197) in mouse. This evidence concerns the gene CLCN5 and nephrocalcinosis.