HMGI/Y (HMG1A) is usually expressed at low levels in adult tissues, but found at high expression levels in embryonic and neoplastic tissues (Chiappetta et al., 1996), its aberrant expression has been associated with tumorigenesis (Tkachenko et al., 1997) and high expression is a requirement for the production of CXC ligand 1, a major effector of tumor growth(Amiri et al., 2006). Here, HMGA1 is linked to neoplasm.