TLR1 and invasive breast carcinoma: Finally, inheritance of the homozygous minor variant of the TLR1/TLR6/TLR10 rs7696175 locus (situated in proximity to all three TLR promoters) was associated with a large fourfold increase in BrCa risk (OR = 4.11; 95% CI = 1.28, 13.24) among African-American women as opposed to little or no risk among women of European ancestry (OR = 1.20; 95% CI = 0.93, 1.53) (19).