IRAK4 and cancer: As shown in Figure 1, IRAK4 mediated signaling results in a wide range of cancer-related cellular responses, including: imbalances in cell survival/cell death; production of pro-inflammatory cytokines and chemokines; expression of interferons and interferon-inducible genes; and release of matrix metalloproteinases that degrade extracellular matrix and facilitate cell migration/metastasis.