ESR1 and neoplasm: For instance, IRAK4 rs4251545 was associated with a 2.56-fold increase in invasive disease (OR = 2.56; 95% CI = 1.1–5.91); whereas, inheritance of the IRAK2 rs242724 minor alleles were linked to non-aggressive disease (i.e., tumor size <2 cm, ER + /PR + /Her-2 neu+ status).