This result showed that the abnormal expression of RAF1, MAPT, PTGS2, CDKN2A, CAMK2A, NTRK2, AGER, ADRBK1, MCM3AP, and STUB1 might be involved in the structural, functional, and behavioral consequences of AD-associated pathology in SAMP8 mice. This evidence concerns the gene RAF1 and Alzheimer disease.