EGFR and cancer: The present study clearly showed that the SAMP8 mice involved a dysfunction of many cellular pathways, including LTP, focal adhesion, MAPK signaling pathway (Xiao et al., 2009b), GnRH signaling pathway (Yuan et al., 2005), ErbB signaling pathway, adherens junction (Ueno et al., 2001), cell cycle (Casadesus et al., 2012) and pathways in cancer (Gutierrez-Cuesta et al., 2008) (Figure 5).