This finding indicated that RAF1, MAPT, PTGS2, CDKN2A, CAMK2A, NTRK2, AGER, ADRBK1, MCM3AP, and STUB1 might mainly target these 12 pathways, resulting in the typical symptoms of AD observed in SAMP8 mice. The gene discussed is CDKN2A; the disease is Alzheimer disease.