However, the neurotrophin signaling pathway, pathways in cancer, MAPK signaling pathway, GnRH signaling pathway, cell cycle, ErbB signaling pathway, oocyte meiosis, adherens junction, long-term potentiation (LTP), AD, focal adhesion, and vascular smooth muscle contraction were enriched (Figure 5) (Supplement Table 5). Here, GNRH1 is linked to Alzheimer disease.