This indicated that RAF1, MAPT, PTGS2, CDKN2A, CAMK2A, NTRK2, AGER, ADRBK1, MCM3AP, and STUB1 might induce SAMP8 mice to demonstrate patho-physiological hallmarks of AD by regulating apoptosis and synaptic transmission. Here, CDKN2A is linked to Alzheimer disease.