This result showed that the abnormal expression of RAF1, MAPT, PTGS2, CDKN2A, CAMK2A, NTRK2, AGER, ADRBK1, MCM3AP, and STUB1 might be involved in the structural, functional, and behavioral consequences of AD-associated pathology in SAMP8 mice. The gene discussed is CDKN2A; the disease is Alzheimer disease.