Stroke upregulated Shh signal in SVZ neural progenitor cells and blockage of the Shh pathway with cyclopamine, a specific inhibitor of Smo, suppressed stroke-induced neural progenitor cell proliferation and attenuated EPO-increased neural progenitor cell proliferation (Wang et al., 2007; Liu et al., 2013a). The gene discussed is SHH; the disease is stroke disorder.