NES and Stroke: By tracking progeny of SVZ nestin lineage neural progenitor cells in ischemic brain of transgenic mice at age of 12 months, a study shows that stroke increased nestin lineage OPCs and oligodendrocytes and that administration of sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor, further augmented nestin lineage OPCs and oligodendrocytes in peri-infarct corpus callosum and striatum (Zhang et al., 2012).