Similarly, while the effects of CRF-related peptides on locomotor activity, aggression and anxiety-like behaviors in salmonids may be at least partly mediated through the serotonergic system (Clements et al., 2003; Carpenter et al., 2007, 2009; Backström et al., 2011), the appetite-suppressing actions of i.c.v. CRF and UI in this study were not affected by co-injection of the 5-HT1−2 receptor antagonist, methysergide. The gene discussed is CRH; the disease is Anxiety.