The central nucleus of the amygdala (CeA) is a key component of an extended brain circuitry involved in stress responses and anxiety-like behaviors and is an important structure for CRF-mediated responses as it contains one of the highest concentrations of CRF immunoreactive neurons outside of the PVN (Cummings et al., 1983; Swanson et al., 1983; Cassell and Gray, 1989; Shimada et al., 1989). Here, CRH is linked to Anxiety.