In contrast to the wealth of evidence pointing to a role for CRF in the CeA in stress-induced anxiety-like behavior, long-term (4 month) viral-mediated overexpression of CRF in the CeA actually reduced anxiety-like behaviors (Regev et al., 2011) whereas long-term knockdown leads to decreases in anxiety-like behavior and cortisol responses to acute stressors (Regev et al., 2012). The gene discussed is CRH; the disease is Anxiety.