Measures of hyperactivity of the CRF system have been consistently implicated in the pathophysiology/etiology of a number of psychiatric conditions including anxiety disorders such as PTSD as well as depression and addiction (for reviews, see Arborelius et al., 1999; Bale and Vale, 2004; Ronan and Summers, 2011). The gene discussed is CRH; the disease is depressive symptom measurement.