DR + AA rats, treated with OMZ, INS and PTX showed decrease in ulcer index by 39.3, 38.6 and 43.3% respectively (near to NR + AA level) while, MSE showed decrease by 63.8%, less than the value of NR + AA rats indicating better healing by MSE compared to OMZ, INS or PTX (Figure 2). The gene discussed is INS; the disease is ulcer disease.