In a newly presented study where seven different markers for distinction between high grade serous and clear cell ovarian carcinoma did though p53 in combination with p21 (and Cyclin E, ER, HNF-1b, WT1 and Ki-67) correctly classify 84% of tumors with high grade serous compared with clear cell ovarian carcinoma [27]. The gene discussed is CCNE1; the disease is ovarian clear cell cancer.