Differences in the immunohistochemical profil for Napsin A and the apoptosis regulators p21, p53 and concomitant p21 and p53 between the groups of clear cell carcinomas and other histological subtypes of tumors in one group (Type I and Type II) were found in the present study, whereas differences in the p27 status were limited to comparison between clear cell tumors and Type I tumors. Here, TP53 is linked to clear cell adenocarcinoma.