Differences in the immunohistochemical profile for Napsin A and the apoptosis regulators p21, p53 and concomitant p21 and p53 between the groups of clear cell carcinomas and other histological subtypes of tumors in one group (Type I and Type II) were detected in the present study, whereas differences in the p27 status were limited to comparison between clear cell tumors and Type I tumors. The gene discussed is TP53; the disease is clear cell adenocarcinoma.