HGF and Splenomegaly: HGF can also be associated with syndromes like Cowden's syndrome (multiple hamartomas), Zimmerman-Laband syndrome (defects of bone, nail, ear, nose, and splenomegaly), Murray-Purelie Drescher syndrome (multiple dental hyaline tumors), Rutherford syndrome (corneal dystrophy), Jones syndrome (sensori-neural deafness), and Cross syndrome (hypopigmentation with athetosis) [1, 6].