GNAI1 and type 2 diabetes mellitus: The level of NE and the number of Gi/o-coupled α2-ARs in the frontal cortex, septal area, amygdala, hypothalamus, and medulla of 4–16-week-old db/db mice with T2DM-like state were, on the contrary, elevated compared to those of control animals and this increase correlated with the changes in blood glucose level and body weight [43].