At the same time, the mRNA level encoding β2-AR in the heart of rats with 14-week STZ T1DM was increased, but the density of β2-AR protein was, on the contrary, decreased which can be attributed to the increased rate of β2-AR degradation and posttranslational modifications preventing the translocation of this receptor from the endoplasmic reticulum to the plasma membrane [86]. The gene discussed is ADRB2; the disease is type 1 diabetes mellitus.