ADRB2 and type 2 diabetes mellitus: In the liver membranes isolated from ob/ob mice with hyperglycemia, hyperinsulinemia, and obesity typical of T2DM, the number of β2-AR binding sites was increased threefold, and the response of AC to catecholamines was significantly enhanced as compared to both control animals and db/db mice, the other animal model of T2DM [146].