GNAI1 and type 1 diabetes mellitus: At the same time, prolonged T1DM induced by the treatment of animals with dropping doses of STZ (30–40 mg/kg) led to a weakening of the inhibitory effect of NE on forskolin-stimulated AC activity in the myocardial membranes and to a decrease of NE-induced stimulation of Gi protein GppNHp-binding capacity [32].