ADCY5 and type 1 diabetes mellitus: The mRNA expression and the protein content of AC5 and AC6 were significantly lower in the diabetic mesenteric artery, as compared to control, and the stimulation of the basal AC activity by the water-soluble forskolin analog NKH477, a putative AC5 activator, was significantly impaired in the mesenteric arteries from rats with STZ-induced T1DM [108].