A special mention deserves the fact that the acute hyperglycemia caused by very short STZ T1DM also led to a decrease of functional activity of Gi-coupled AC signaling cascades, as it follows from a significant weakening of inhibition of forskolin-stimulated AC activity and stimulation of GppNHp binding capacity of Gi proteins induced by somatostatin in the skeletal muscles of rats with one-day T1DM [36]. Here, GNAI1 is linked to type 1 diabetes mellitus.