ADCYAP1 and type 2 diabetes mellitus: These data speak in favor of the fact that PACAP counteracted the lipotoxicity, acting via PAC-1 and other types of PACAP receptors, and protected neuronal cells from apoptosis in the diabetic brain, which suggests a potential therapeutic role of PACAP receptor agonists in the treatment of neurological complications induced by T2DM and obesity [75].