To further investigate the effects of total saponin (TS) and triterpenoid saponins 1–5 on the proliferation of cancer cells, a panel of three human cancer cell lines, including the human cervix carcinoma cell model (High COX-2 expressed HeLa cells induced by LPS treatment) and two human hepatocellular carcinoma cell lines (BEL-7402 and HepG2) were used in the present study. The gene discussed is PTGS2; the disease is cancer.