Deregulation in Hsp 70 chaperones appears to be implicated in the processes of tau aggregation, so compounds that bind Hsp 70 chaperones are under investigation as possible treatment compounds for neurodegenerative diseases, since there is evidence that Hsp 70 inhibition leads to tau ubiquitination and clearance through ubiquitin-proteasome system (40). The gene discussed is MAPT; the disease is neurodegenerative disease.