Thus, these two distinct animal models of essential tremor (a1−/− and harmaline-induced tremors) likely result from different mechanisms, such as the involvement of distinct T-type Ca2+ channel isoforms (e.g., Harmaline tremor by CaV3.1 and a1−/− tremor by CaV3.2 or 3.3). Here, CACNA1H is linked to Tremor.