Administration of ATP produces long-lasting allodynia, probably via P2X2/P2X3 receptors (Nakagawa et al., 2007) and it has been suggested that P2X3/P2X2/3 receptor-dependent cytosolic phospholipase A2 (cPLA2) activity in primary sensory neurons is a key event in neuropathic pain (Tsuda et al., 2007). Here, P2RX2 is linked to Pain.