Vascular endothelial growth factor (VEGF)-mediated angiogenesis and mammalian target of rapamycin (mTOR)-mediated regulation of cell growth, cell proliferation, cellular metabolism, and angiogenesis have been identified as key factors in the development of renal cell carcinoma (RCC) [1, 2]. Here, MTOR is linked to hereditary clear cell renal cell carcinoma.