We previously demonstrated that the low expression of favorable NB genes (EFNB2, EFNB3, EPHB6, NTRK1, CD44 and MIZ-1), as well as that of the tumor growth suppressive gene, EPHA2, in NB cell lines was due to epigenetic silencing (9,14,17). The gene discussed is EPHB6; the disease is neoplasm.