MYC and neoplasm: Furthermore, several lines of evidence refute the Warburg hypothesis: i) Weinhouse’s re-evaluation of Warburg’s data indicated that tumor tissues are in fact active in mitochondria-driven OXPHOS (27); ii) several types of cancer cells express high levels of MYC family proteins that stimulate mitochondrial biogenesis, glycolysis and glutaminolysis, thus facilitating cancer cell growth (28).