EGFR and lung carcinoma: Furthermore, CDC37 is a known co-chaperone of activated kinases with HSP90 and HSP90 has been implicated in chaperoning aberrant RTK such as mutant EGFR and EML4-ALK in lung cancer (Shimamura et al, 2005; Chen et al, 2010; Sequist et al, 2010a, Sequist et al, 2010b).