EGFR and lung carcinoma: ERBB2, which was found in EGFR complexes in the lung cancer cell lines, and in complex with wild-type EGFR in the AALE system, was chosen based on its potential as an important heterodimeric protein with EGFR and ERBB3 and its role in EGFR TKI resistance (Takezawa et al, 2012), GRP78 (found in lung cancer cell lines and in both mutant and wild-type EGFR complexes in AALE) and CDC37 (found in lung cancer cell lines but not in AALE) were chosen as chaperones with potential functional importance.