When these proteins were mapped back onto the original EGFR interactome, we visually identified three functional clusters, in addition to EGFR, that strongly affected cellular proliferation in these EGFR-addicted lung cancer cells (Figure 3D, left panel), including proteins serving as components of the MAPK/Rho pathway (SHC1, GRB2, MK12, and ARHG5), the PI3K pathway (PK3CA, P55G, and P85B), and kinases associated with CDC37 (CD11A, CD11B, CDK9, and ARAF). This evidence concerns the gene SHC1 and lung carcinoma.