We further defined specificity of components of the 14 core network for cells dependent on mutant EGFR for survival and identified EGFR, GRB2, MK12, SHC1, ARAF, CD11B, ARHG5, GLU2B, and CD11A as especially vulnerable in EGFR-mutated and EGFR-dependent lung cancer cell lines. Here, EGFR is linked to lung cancer.