PIK3R2 and lung cancer: When these proteins were mapped back onto the original EGFR interactome, we visually identified three functional clusters, in addition to EGFR, that strongly affected cellular proliferation in these EGFR-addicted lung cancer cells (Figure 3D, left panel), including proteins serving as components of the MAPK/Rho pathway (SHC1, GRB2, MK12, and ARHG5), the PI3K pathway (PK3CA, P55G, and P85B), and kinases associated with CDC37 (CD11A, CD11B, CDK9, and ARAF).