Although REMBRANDT database only uses a categorization for the tissue origin and doesn't include WHO grading system as a component of the analysis, the overall conclusion demonstrated both by us and the REMBRANDT is that KAL1 is elevated in all tumors compared with nontumor samples and shows a particular association with astrocytoma and glioblastoma. This evidence concerns the gene ANOS1 and astrocytoma (excluding glioblastoma).