The findings shows that weak expression of SOX11 is related to methylation of SOX11 gene promoter in the tissues of nasopharyngeal carcinoma, and SOX11 re-expression is associated with demethylation of SOX11 gene by 5-aza-2'-deoxycytidine treated in CNE2 cells. This evidence concerns the gene SOX11 and nasopharyngeal carcinoma.