The previous study demonstrated that loss of DAPK expression is associated with aberrant promoter region methylation in nasopharngeal cancer cell line(CNE2) and laryngeal cancer cell line(Hep-2), 5 - aza-2'-deoxycytidine may reactivate DAPK genes silenced by promoter region hypermethylation and can slow the growth of Hep-2 cells and CNE2 cells in vitro and in vivo [24,25]. Here, DAPK1 is linked to laryngeal carcinoma.