LMP2A up-regulates cellular DNMT1 through the phosphorylation of STAT3, resulting in the repression of tumor suppressor genes, such as PTEN, through promoter methylation (immunohistochemistry confirmed the concurrent expression of pSTAT3 and DNMT1 in neoplastic cells of LLC gastric carcinoma in vivo [20]). The gene discussed is STAT3; the disease is gastric carcinoma.