However, the data only suggested an evident trend towards a worse prognosis but no significant association between high S100A4 expression and CRC patients’ age (old vs. young), gender (female vs. man), differentiation (poorly vs. well and moderately), distant metastasis (M1 vs. M0), tumour size (size ≥5 cm vs. <5 cm), vascular invasion (yes vs. no), and recurrence (yes vs. no) (Table 2, Additional file 1: Figure S1). This evidence concerns the gene S100A4 and neoplasm.