Combined data from the three studies suggested that increased S100A4 levels were significantly correlated with DFS in CRC patients, yielding a combined HR of 2.16 (95% CI: 1.53–3.05, P <0.001), without significant heterogeneity in the data (P = 0.667, I2 = 0.0%) (Figure 3, Table 2). Here, S100A4 is linked to colorectal carcinoma.