CSF3 and Decreased total neutrophil count: Although in our trial there was one death due to grade 4 febrile neutropenia, frequency of grade 4 hematologic toxicity was low, and it is likely that this low incidence was due to Jones et al. [24] compared accelerated epirubicin or doxorubicin with cyclophosphamide given at 2-week interval with G-CSF support with 3-week intervals in early breast cancer and observed fewer grade 3/4 neutropenia.