For the entire cohort, the only univariate predictors of the peak dose Ach-induced dilation include BMI and hsCRP Age, waist circumference, lipid profile, fasting glucose, HOMA-IR (Homeostasis Model of Assessment-Insulin Resistance), QUICKI (quantitative insulin sensitivity check index), SBP, and DBP were not significant predictors of vasodilation to peak Ach dose. The gene discussed is INS; the disease is Insulin resistance.