Although PrP in transmissible spongiform encephalopathies (TSEs) is the most representative protein of this phenomenon, APP (amyloid precursor protein) and tau in Alzheimer's disease (AD) as well as in frontotemporal dementias (FTD), α-Synuclein in parkinson's diseases (PD) and superoxide dismutase 1 (SOD-1), and the 43KDa TAR (trans-activator regulatory) DNA binding protein (TDP43) in amyotrophic lateral sclerosis (ALS) are also involved in protein misfolding propagation. The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.