STAT6 and Increased total eosinophil count: To next evaluate the impact of IL-6 deficiency on the innate immune response to H. polygyrus infection, we then assessed the generation of eosinophilia, which in other helminth infections can occur independently of the adaptive Th2 compartment in nu/nu [25], STAT-6−/− [26], and RAG-deficient [27] animals.