In the absence of IL-6, significantly fewer MLNC Treg cells expressed GATA-3 (Fig. 4F and G), and in particular expression levels (as measured by intensity of GATA-3 staining within Foxp3+ T cells) were significantly diminished both in steady state and in response to infection at a time-point preceding effector cell dysregulation (day 5; Fig. 4H). Here, FOXP3 is linked to infection.