CASP3 and neoplasm: In contrast, and entirely consistent with our earlier in vitro findings, induction of apoptosis by 17-AAG was observed in HCT116 BAX+/− but not in HCT116 BAX−/− tumor xenografts as measured by the cleavage of caspase-3 on day five following daily i.p doses of 80mg/kg 17-AAG (Figure 6C and 6D).