To delineate the mechanism by which RhoGDI2 promotes gastric cancer cell invasion and chemoresistance, we performed two-dimensional gel electrophoresis (2-DE) on proteins that were derived from a RhoGDI2-overexpressing SNU-484 human gastric cancer cell line and control cells, and noted that levels of 14-3-3σ, which is a member of the multifunctional 14-3-3 protein family, were significantly reduced [23]. This evidence concerns the gene YWHAQ and gastric cancer.