ARHGDIB and malignant colon neoplasm: However, we recently suggested that RhoGDI2 enhances the chemoresistance of gastric cancer through the upregulation of Bcl-2 expression as well as promotes tumor growth and malignant progression.22 Consistent with our results, Zheng et al. suggested that the knockdown of RhoGDI2 expression significantly increases the sensitivity of colon cancer cells to 5-FU [34], and that the ectopic expression of RhoGDI2 in gastric cancer cells induces resistance to 5-FU and reverses 5-FU-induced G2/M phase arrest [35].