Since mitogen-activated protein kinase (MAPK) pathways are implicated in the execution of apoptosis by different cytotoxic agents and p38/JNK kinase activities have been known to be increased in RhoGDI2-depleted breast cancer cells [15], we first assessed whether the activities of these apoptosis-related kinases are suppressed in RhoGDI2-overexpressing gastric cancer cells. Here, WNK2 is linked to gastric cancer.