For the cytoplasmic staining pattern, ezrin was weakly positive in only 11.5% of normal cervix samples, but showed strong and diffuse staining pattern in cervical cancers (SCC and AC) and their precancerous diseases (CIN and CGIN), indicating that the altered localization of ezrin is useful in the early diagnosis of cervical cancers and precancerous diseases. This evidence concerns the gene EZR and cervical squamous intraepithelial neoplasia.