For example, in addition to degrading the extracellular matrix, MT1-MMP plays an important role in tumor angiogenesis [47] through upregulation of VEGF [48] and immunoregulation through its effect on the release and activation of cytokines such as TGF-β, a well-known suppressor of T-lymphocyte reaction against cancer [49]. Here, TGFB1 is linked to neoplasm.