IGFBP7 and type 2 diabetes mellitus: Figure 2 demonstrates that IGFBP7 DNA methylation levels were significantly increased in newly diagnosed T2D patients compared with NGT subjects at all three CpG sites (P1: 10.4% vs. 6.2%; P2: 14.3% vs. 8.6% and P3: 44.4% vs. 22.7%, all P < 0.01).