In 2008, Kutsukake et al.[18] developed a novel IGFBP-7 ELISA using two IGFBP-7 antibodies and analyzed serum IGFBP-7 levels in 33 male hemodialysis patients, including 18 patients with and 15 patients without T2D. This evidence concerns the gene IGFBP7 and type 2 diabetes mellitus.