Statistically significant increases in Annexin V+ and PI+ apoptotic cells were observed in miR-34c-3p (28.49%) and miR-34c-5p (28.14%) mimic treatment groups in U251 glioblastoma cells, compared with normal (6.57%) or NC (6.3%) groups (Fig. 3A). The gene discussed is ANXA5; the disease is glioblastoma.