CCR6 and cancer: Fig. 3 shows the immunohistochemical results for CCL20 and CCR6 in UC-associated and sporadic colon cancer. CCL20 expression was observed in the nuclei of the UC-associated and sporadic colon cancer cells. In contrast, CCR6 expression was observed in the cytoplasm of the cancer cells. The expression of CCR6, but not CCL20, was increased in UCAC compared with sporadic colon cancer (P=0.0316; Table IV).