To the best of our knowledge, there have been no studies regarding predictive factors in HBV-related HCC patients treated with ETV who have undergone curative therapy, despite the fact that ETV is now a first-line NA therapy for patients with CHB due to the superior efficacy of HBV DNA suppression, ALT normalization and histological improvement compared with LAM and ADV treatment (14–18). This evidence concerns the gene GPT and hepatocellular carcinoma.