Ebert et al(9) reported the expression of Foxp3 in not only Tregs, but also in melanoma cells in metastatic melanoma tissue and tumor cell lines derived from melanoma (SK-Mel-1 and SK-Mel-28) and other solid tumors [A172 and U-87 MG (glioma); DU 145, PC-3 and LN-CaP (prostate cancer); A549, CaLu-6 and NCI-H460 (lung cancer); HCT116, Caco-2 and SW480 (colorectal cancer); HT-1376, HT-1197 and HT-5637 (bladder cancer); and MCF7, MDA-MB-231 and MDA-MD-468 (breast cancer)] (10). The gene discussed is FOXP3; the disease is metastatic melanoma.