Lirdprapamongkol et al(92) have reported that the poorly-differentiated HCC cell line, SK-Hep-1, with mesenchymal features (high invasiveness and expressing vimentin, with no E-cadherin) could form VM in vitro, while the well-differentiated cell line HepG2 did not form VM. The gene discussed is CDH1; the disease is hepatocellular carcinoma.