In addition to their use as therapeutic drugs in human medicine (AD, myasthenia gravis, glaucoma, Lewy bodies, Parkinson’s disease), these reversible AChE inhibitors have been applied as pesticides, then as parasiticides in veterinary medicine, and in prophylaxis of organophosphorus compounds (OPs) poisoning as well [67]. The gene discussed is ACHE; the disease is myasthenia gravis.