Co-administration of the positive allosteric modulator (PAM) PNU-120596 with Donepezil increases its effective dose range in learning/memory-related tasks in different young and age-impaired animal models [150], suggesting that α7-nAChR-selective PAMs have potential as adjunctive treatments with acetylcholinesterase inhibitors (e.g., Donepezil) for age-related illnesses such as AD as well memory disorders not necessarily associated with advanced age. The gene discussed is ACHE; the disease is Alzheimer disease.