AKT1 and glioblastoma: Among the 20 most significantly mutated genes were regulators of transforming growth factor beta signaling (RBBP9 and DPT) and regulators of AKT signaling (TCL1B) (Pruitt et al., 2012) as well as other genes that have not been tested specifically for their role in GBM recurrence (Supplementary Table S3).