As expected, the present results showed marked obese states (increased body weight and fat depositions, adipocyte hypertrophy), hyperglycemia, hyperlipidemia (increased serum total cholesterol, triglyceride and LDL levels with decreased HDL levels), liver (increased serum AST and ALT level with severe steatohepatitis) and kidney damages (fatty changes in tubules, serum BUN and creatinine elevations) by 91 days of continuous HFD supply. The gene discussed is GPT; the disease is hyperlipidemia.