Because the Kv3 potassium channels are essential in CNS physiological activity and Kv3.4 subunits were shown to be involved in responses to chronic hypoxia [57] in Parkinson’s [55] and Alzheimer’s [58] diseases, selective targeting of the aforementioned subunits will have therapeutic utility in CNS disorders. Here, KCNC4 is linked to Parkinson disease.