Also, despite some evidence supporting the ability of antioxidants to improve insulin action, it is not currently recommended to supplement antioxidants in patients with impaired insulin action, like type 2 diabetes [165]; this is also because of some evidence suggesting potential harm, including increase in all-cause mortality, with vitamin E, carotene, selenium, and other antioxidant supplementation [166–168]. The gene discussed is INS; the disease is type 2 diabetes mellitus.